PoplarV1, Main, Exploration, bibRecord, 001B46

Self-assembly of cricoid proteins induced by "soft nanoparticles": an approach to design multienzyme-cooperative antioxidative systems.

Identifieur interne : 001B46 ( Main/Exploration ); précédent : 001B45; suivant : 001B47

Self-assembly of cricoid proteins induced by "soft nanoparticles": an approach to design multienzyme-cooperative antioxidative systems.

Source :

ACS nano [ 1936-086X ] ; 2015.

RBID : pubmed:25952366

Descripteurs français

English descriptors

KwdEn :
- Antioxidants (chemistry), Antioxidants (metabolism), Biocatalysis (MeSH), Cell Line, Tumor (MeSH), Dendrimers (chemistry), Glutathione Peroxidase (metabolism), Humans (MeSH), Models, Molecular (MeSH), Nanowires (chemistry), Plant Proteins (chemistry), Plant Proteins (metabolism), Populus (MeSH), Protein Aggregates (MeSH), Protein Conformation (MeSH), Static Electricity (MeSH), Superoxide Dismutase (metabolism).
MESH :
- chemical , chemistry : Antioxidants, Dendrimers, Plant Proteins.
- chemical , metabolism : Antioxidants, Glutathione Peroxidase, Plant Proteins, Superoxide Dismutase.
- chemistry : Nanowires.
- Biocatalysis, Cell Line, Tumor, Humans, Models, Molecular, Populus, Protein Aggregates, Protein Conformation, Static Electricity.

Abstract

A strategy to construct high-ordered protein nanowires by electrostatic assembly of cricoid proteins and "soft nanoparticles" was developed. Poly(amido amine) (PAMAM) dendrimers on high generation that have been shown to be near-globular macromolecules with all of the amino groups distributing throughout the surface were ideal electropositive "soft nanoparticles" to induce electrostatic assembly of electronegative cricoid proteins. Atomic force microscopy and transmission electron microscopy all showed that one "soft nanoparticle" (generation 5 PAMAM, PD5) could electrostatically interact with two cricoid proteins (stable protein one, SP1) in an opposite orientation to form sandwich structure, further leading to self-assembled protein nanowires. The designed nanostructures could act as versatile scaffolds to develop multienzyme-cooperative antioxidative systems. By means of inducing catalytic selenocysteine and manganese porphyrin to SP1 and PD5, respectively, we successfully designed antioxidative protein nanowires with both excellent glutathione peroxidase and superoxide dismutase activities. Also, the introduction of selenocysteine and manganese porphyrin did not affect the assembly morphologies. Moreover, this multienzyme-cooperative antioxidative system exhibited excellent biological effect and low cell cytotoxicity.

DOI: 10.1021/acsnano.5b01311
PubMed: 25952366

Affiliations:

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Le document en format XML

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<author><name sortKey="An, Guo" sort="An, Guo" uniqKey="An G" first="Guo" last="An">Guo An</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Luo, Quan" sort="Luo, Quan" uniqKey="Luo Q" first="Quan" last="Luo">Quan Luo</name>
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<author><name sortKey="Yu, Shuangjiang" sort="Yu, Shuangjiang" uniqKey="Yu S" first="Shuangjiang" last="Yu">Shuangjiang Yu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012</wicri:regionArea>
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<region type="province">Jilin</region>
</placeName>
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<author><name sortKey="Liu, Junqiu" sort="Liu, Junqiu" uniqKey="Liu J" first="Junqiu" last="Liu">Junqiu Liu</name>
<affiliation wicri:level="4"><nlm:affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
<orgName type="university">Université de Jilin</orgName>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
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<series><title level="j">ACS nano</title>
<idno type="eISSN">1936-086X</idno>
<imprint><date when="2015" type="published">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants (chemistry)</term>
<term>Antioxidants (metabolism)</term>
<term>Biocatalysis (MeSH)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Dendrimers (chemistry)</term>
<term>Glutathione Peroxidase (metabolism)</term>
<term>Humans (MeSH)</term>
<term>Models, Molecular (MeSH)</term>
<term>Nanowires (chemistry)</term>
<term>Plant Proteins (chemistry)</term>
<term>Plant Proteins (metabolism)</term>
<term>Populus (MeSH)</term>
<term>Protein Aggregates (MeSH)</term>
<term>Protein Conformation (MeSH)</term>
<term>Static Electricity (MeSH)</term>
<term>Superoxide Dismutase (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agrégats de protéines (MeSH)</term>
<term>Antioxydants (composition chimique)</term>
<term>Antioxydants (métabolisme)</term>
<term>Biocatalyse (MeSH)</term>
<term>Conformation des protéines (MeSH)</term>
<term>Dendrimères (composition chimique)</term>
<term>Glutathione peroxidase (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Modèles moléculaires (MeSH)</term>
<term>Nanofils (composition chimique)</term>
<term>Populus (MeSH)</term>
<term>Protéines végétales (composition chimique)</term>
<term>Protéines végétales (métabolisme)</term>
<term>Superoxide dismutase (métabolisme)</term>
<term>Électricité statique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antioxidants</term>
<term>Dendrimers</term>
<term>Plant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term>
<term>Glutathione Peroxidase</term>
<term>Plant Proteins</term>
<term>Superoxide Dismutase</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanowires</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Antioxydants</term>
<term>Dendrimères</term>
<term>Nanofils</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term>
<term>Glutathione peroxidase</term>
<term>Protéines végétales</term>
<term>Superoxide dismutase</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Biocatalysis</term>
<term>Cell Line, Tumor</term>
<term>Humans</term>
<term>Models, Molecular</term>
<term>Populus</term>
<term>Protein Aggregates</term>
<term>Protein Conformation</term>
<term>Static Electricity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Agrégats de protéines</term>
<term>Biocatalyse</term>
<term>Conformation des protéines</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles moléculaires</term>
<term>Populus</term>
<term>Électricité statique</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">A strategy to construct high-ordered protein nanowires by electrostatic assembly of cricoid proteins and "soft nanoparticles" was developed. Poly(amido amine) (PAMAM) dendrimers on high generation that have been shown to be near-globular macromolecules with all of the amino groups distributing throughout the surface were ideal electropositive "soft nanoparticles" to induce electrostatic assembly of electronegative cricoid proteins. Atomic force microscopy and transmission electron microscopy all showed that one "soft nanoparticle" (generation 5 PAMAM, PD5) could electrostatically interact with two cricoid proteins (stable protein one, SP1) in an opposite orientation to form sandwich structure, further leading to self-assembled protein nanowires. The designed nanostructures could act as versatile scaffolds to develop multienzyme-cooperative antioxidative systems. By means of inducing catalytic selenocysteine and manganese porphyrin to SP1 and PD5, respectively, we successfully designed antioxidative protein nanowires with both excellent glutathione peroxidase and superoxide dismutase activities. Also, the introduction of selenocysteine and manganese porphyrin did not affect the assembly morphologies. Moreover, this multienzyme-cooperative antioxidative system exhibited excellent biological effect and low cell cytotoxicity. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25952366</PMID>
<DateCompleted><Year>2016</Year>
<Month>04</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>05</Month>
<Day>26</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1936-086X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>5</Issue>
<PubDate><Year>2015</Year>
<Month>May</Month>
<Day>26</Day>
</PubDate>
</JournalIssue>
<Title>ACS nano</Title>
<ISOAbbreviation>ACS Nano</ISOAbbreviation>
</Journal>
<ArticleTitle>Self-assembly of cricoid proteins induced by "soft nanoparticles": an approach to design multienzyme-cooperative antioxidative systems.</ArticleTitle>
<Pagination><MedlinePgn>5461-9</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1021/acsnano.5b01311</ELocationID>
<Abstract><AbstractText>A strategy to construct high-ordered protein nanowires by electrostatic assembly of cricoid proteins and "soft nanoparticles" was developed. Poly(amido amine) (PAMAM) dendrimers on high generation that have been shown to be near-globular macromolecules with all of the amino groups distributing throughout the surface were ideal electropositive "soft nanoparticles" to induce electrostatic assembly of electronegative cricoid proteins. Atomic force microscopy and transmission electron microscopy all showed that one "soft nanoparticle" (generation 5 PAMAM, PD5) could electrostatically interact with two cricoid proteins (stable protein one, SP1) in an opposite orientation to form sandwich structure, further leading to self-assembled protein nanowires. The designed nanostructures could act as versatile scaffolds to develop multienzyme-cooperative antioxidative systems. By means of inducing catalytic selenocysteine and manganese porphyrin to SP1 and PD5, respectively, we successfully designed antioxidative protein nanowires with both excellent glutathione peroxidase and superoxide dismutase activities. Also, the introduction of selenocysteine and manganese porphyrin did not affect the assembly morphologies. Moreover, this multienzyme-cooperative antioxidative system exhibited excellent biological effect and low cell cytotoxicity. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Hongcheng</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Miao</LastName>
<ForeName>Lu</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jiaxi</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fu</LastName>
<ForeName>Shuang</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>An</LastName>
<ForeName>Guo</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Si</LastName>
<ForeName>Chengye</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dong</LastName>
<ForeName>Zeyuan</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Quan</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Shuangjiang</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>‡Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130021, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Jiayun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Junqiu</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>†State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>05</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>ACS Nano</MedlineTA>
<NlmUniqueID>101313589</NlmUniqueID>
<ISSNLinking>1936-0851</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050091">Dendrimers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C104700">PAMAM Starburst</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D066329">Protein Aggregates</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber>
<NameOfSubstance UI="D005979">Glutathione Peroxidase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber>
<NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055162" MajorTopicYN="N">Biocatalysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050091" MajorTopicYN="N">Dendrimers</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005979" MajorTopicYN="N">Glutathione Peroxidase</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053770" MajorTopicYN="N">Nanowires</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D066329" MajorTopicYN="N">Protein Aggregates</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011487" MajorTopicYN="N">Protein Conformation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055672" MajorTopicYN="N">Static Electricity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013482" MajorTopicYN="N">Superoxide Dismutase</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">PAMAM dendrimer</Keyword>
<Keyword MajorTopicYN="N">antioxidation</Keyword>
<Keyword MajorTopicYN="N">artificial selenoenzyme</Keyword>
<Keyword MajorTopicYN="N">cricoid protein</Keyword>
<Keyword MajorTopicYN="N">multienzyme-cooperative</Keyword>
<Keyword MajorTopicYN="N">protein nanowire</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>5</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>5</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>4</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25952366</ArticleId>
<ArticleId IdType="doi">10.1021/acsnano.5b01311</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Dongbei</li>
<li>Jilin</li>
</region>
<settlement><li>Changchun</li>
</settlement>
<orgName><li>Université de Jilin</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><region name="Jilin"><name sortKey="Sun, Hongcheng" sort="Sun, Hongcheng" uniqKey="Sun H" first="Hongcheng" last="Sun">Hongcheng Sun</name>
</region>
<name sortKey="An, Guo" sort="An, Guo" uniqKey="An G" first="Guo" last="An">Guo An</name>
<name sortKey="Dong, Zeyuan" sort="Dong, Zeyuan" uniqKey="Dong Z" first="Zeyuan" last="Dong">Zeyuan Dong</name>
<name sortKey="Fu, Shuang" sort="Fu, Shuang" uniqKey="Fu S" first="Shuang" last="Fu">Shuang Fu</name>
<name sortKey="Li, Jiaxi" sort="Li, Jiaxi" uniqKey="Li J" first="Jiaxi" last="Li">Jiaxi Li</name>
<name sortKey="Liu, Junqiu" sort="Liu, Junqiu" uniqKey="Liu J" first="Junqiu" last="Liu">Junqiu Liu</name>
<name sortKey="Luo, Quan" sort="Luo, Quan" uniqKey="Luo Q" first="Quan" last="Luo">Quan Luo</name>
<name sortKey="Miao, Lu" sort="Miao, Lu" uniqKey="Miao L" first="Lu" last="Miao">Lu Miao</name>
<name sortKey="Si, Chengye" sort="Si, Chengye" uniqKey="Si C" first="Chengye" last="Si">Chengye Si</name>
<name sortKey="Xu, Jiayun" sort="Xu, Jiayun" uniqKey="Xu J" first="Jiayun" last="Xu">Jiayun Xu</name>
<name sortKey="Yu, Shuangjiang" sort="Yu, Shuangjiang" uniqKey="Yu S" first="Shuangjiang" last="Yu">Shuangjiang Yu</name>
</country>
</tree>
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Self-assembly of cricoid proteins induced by "soft nanoparticles": an approach to design multienzyme-cooperative antioxidative systems.

Self-assembly of cricoid proteins induced by "soft nanoparticles": an approach to design multienzyme-cooperative antioxidative systems.

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